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Medically Approved

Everolimus oral tablet dosage: A detailed guide

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Form and strengthsDosageFAQHow it's takenCouponOverdoseAsk your doctorBoxed warnings
Doctors prescribe everolimus oral tablet for some types of cancers and benign tumors. It’s also prescribed to prevent organ rejection after certain organ transplants. You take it by mouth one to two times per day.
Medically reviewed by Beth Johnston, PharmD, BCPS
Updated on

This article describes everolimus oral tablet’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for everolimus. If you want to know more about everolimus oral tablet, see this overview article. It covers details about the drug’s uses, side effects, and more.

Everolimus oral tablet is a generic version of the brand-name drugs Afinitor and Zortress. Everolimus also comes in a special tablet that can be dissolved in water for people who cannot swallow the oral tablet, but that form isn’t described in this article. To learn more about the tablet form that can be dissolved in water, talk with your doctor.

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Boxed warnings

This drug has boxed warnings about the following risks. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

See the end of this article for more information about these warnings.

Form and strengths of everolimus

Everolimus oral tablet comes as follows:

  • Forms: tablet that you swallow
  • Strengths: 0.25 milligrams (mg), 0.5 mg, 0.75 mg, 2.5 mg, 5 mg, 7.5 mg, 10 mg

Dosage of everolimus

This article describes the recommended dosages for everolimus oral tablet. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of everolimus oral tablet without your doctor’s recommendation.

Usual recommended dosages of everolimus in adults

Usually, doctors start by prescribing a low dosage of everolimus oral tablet. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of everolimus oral tablet that gives the desired outcome.

ConditionRecommended doseFrequency
kidney transplant0.75 mgtwice per day (as soon as possible after transplant)
liver transplant1 mgtwice per day (starting 30 days after transplant)
renal cell carcinoma (RCC)10 mgonce per day
benign (noncancerous) kidney tumors due to tuberous sclerosis complex (TSC)10 mgonce per day
certain types of brain tumors due to TSCdepends on patient’s weight and lab monitoringonce per day
certain types of breast cancer 10 mgonce per day
pancreatic neuroendocrine tumor (PNET)10 mgonce per day

Dosages of everolimus in children

Everolimus is approved in children 1 year of age and older for TSC tumors that grow in the brain.

The safety and effectiveness of everolimus oral tablets have not been established for use with any other indication in children.

Speak with your child’s doctor to learn more about your child’s specific dosage.

Dosage adjustments for everolimus

Your doctor will prescribe a dosage of everolimus oral tablet based on several factors. These include:

  • the specific condition being treated
  • your age
  • other health conditions you may have
  • other medications you may be taking
  • your response to everolimus, including blood levels and side effects

Missed dose of everolimus

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of everolimus oral tablet. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of everolimus oral tablet and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about everolimus oral tablet and its dosage.

How does the dosage of everolimus compare with the dosage of sirolimus?

Everolimus and sirolimus are both available as oral tablets that you swallow.

Everolimus is taken once or twice daily, depending on why you’re taking it. Sirolimus is taken once daily. The strength of these medications may be different even if they’re prescribed for the same condition.

Depending on your condition, either everolimus or sirolimus may be more appropriate for you to take. Speak with your doctor to learn which one is best for your condition and what dosage is right for you.

Is everolimus taken long term?

Yes, doctors typically prescribe everolimus oral tablet as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

If you have questions about how long you should take everolimus oral tablet, talk with your doctor.

How everolimus is taken

You’ll swallow everolimus oral tablet one to two times per day.

Your doctor may advise that you take this medication around the same time each day. You may also be told to take this medication the same way each day. This means either consistently taking it with food or consistently taking it without food. This helps keep the amount of drug in your body steady over time. And that can help the drug work more effectively.

If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

Everolimus coupon

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Overdose of everolimus

It’s important that you do not take more everolimus oral tablet than your doctor prescribes. Doing so can lead to harmful effects.

What to do if you take too much everolimus

If you think you’ve taken too much everolimus, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for everolimus oral tablet. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of everolimus oral tablet without your doctor’s recommendation. You should take everolimus oral tablet exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Will my dosage of everolimus need to change if I’m taking other medications with it?
  • How long will I need to take everolimus?
  • Will my dosage of everolimus change if my current dose isn’t working?

Boxed warnings for everolimus

This drug has boxed warnings about several risks, which are outlined below. A boxed warning is the most serious warning from the FDA.

Risk of cancer: Medications that weaken your immune system, like everolimus, increase your risk of lymphoma (cancer in your lymph system) and certain skin cancers. This risk seems to be related to the strength of everolimus you take and how long you take it. To help lower this risk, limit your sun exposure and wear protective clothing and sunscreen.

Risk of serious infections: Medications that weaken your immune system, like everolimus, raise the risk of infections. These can be life threatening. Your doctor may prescribe medications to help prevent certain types of infections. Seek medical attention if you have a fever or suspect an infection.

Risk of kidney blood clots: Certain types of blood clots in the kidneys have been reported with everolimus, usually within the first 30 days after an organ transplant.

Risk of kidney damage if taken with high doses of cyclosporine: With a kidney transplant, the combination of everolimus and cyclosporine can decrease kidney function. Because of this, reduced doses of cyclosporine are required.

Risk of death if used after a heart transplant: Everolimus showed a higher risk of death in people who had a heart transplant. Usually, this was associated with infections. For this reason, everolimus is not recommended for people who have had a heart transplant.

You can also talk with your doctor to learn more.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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